• br a Research Team of

  2022-09-01

  

  a Research Team of Cellular Genomics and Molecular Techniques of Investigations, Department of Biology, Faculty of Sciences, University of Moulay Ismail, B.P. 11201 Zitoune Meknès, Morocco b UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, Uni

• br predictions to supporting functional

  2022-09-01

  

   predictions to supporting functional evidence. We provide an interactive resource for exploring driver missense mutations iden-tified from the TCGA (http://karchinlab.github.io/CHASMplus) and a user-friendly tool (http://chasmplus.readthedocs.io/) to pre-dict whether newly observed mutations fr

• br Subgroup OS analysis in

  2022-08-31

  

  3.3. Subgroup OS analysis in lung adenocarcinoma and squamous cell carcinoma patients with stage IIA-IIIB Descriptive analysis for the whole study MCC950 showed that 20.4% of stage IA and 40.6% of stage IB patients received adjuvant chemotherapy, whereas the majority of patients with stage IIA

• br Introduction br Colorectal cancer

  2022-08-31

  

  1. Introduction Colorectal cancer (CRC) is one of the most common malignancies in the world. It is the third most commonly diagnosed cancer among both men and women in the United States, accounting for approximately 135,000 new cases and 50,000 deaths per year [1]. The mortality of colon cancer

• br The peak at cm is assigned to

  2022-08-31

  

  The peak at 1080 cm−1 is assigned to CeC stretch vibrations of the lipid and it is present only in the normal subjects. As the main function of phospholipids in cells is to maintain the membrane structure, the same is observed in normal cases and probably the peak is absent in cancer cases due to

• br Technology Co Ltd China Trypsin was

  2022-08-31

  

  & Technology Co., Ltd., China. Trypsin was obtained from Gibco Co., Ltd., USA. Additionally, Fe3O4 magnetic nanoparticles were synthesized by Xi'an GoldMag Nanobiotech Co., Ltd., China. Dextran-40 was  Journal of Magnetism and Magnetic Materials 481 (2019) 122–128 purchased from Shanghai Hua

• br Cell cycle analysis br After

  2022-08-18

  

  2.3. Cell cycle analysis After treatment with celastrol (0, 0.25, 0.5, and 1 μM) for 24 h, the CCK8 were collected and fixed with 75% ethanol (1 × 106/ml) at -20 °C overnight, washed with phosphate-buffered saline (PBS), and treated with RNase I, then stained with propidium iodide (BD Bioscienc

• br Please cite this article as D

  2022-08-18

  

  Please cite this article as: D. Dheer, J. Nicolas and R. Shankar, Cathepsin-sensitive nanoscale drug delivery systems for cancer therapy and other diseases, Adv. Drug Deliv. Rev., https://doi.org/10.1016/j.addr.2019.01.010 Fig. 20. (a) Sentization of endo-lysosomal membrane in the presence of d

• br P value between the variable and the

  2022-08-17

  

  * P value between the variable and the endpoint diastolic function of the left ventricle, calculated using linear regression analysis. Conclusions This study shows an association between individual RT dose for BC and GLS of the LV. Our results suggest that these adverse effects are associate

• br Five micrometer thick paraffin

  2022-08-17

  

   Five micrometer-thick paraffin sections were mounted on Superfrost Adhesion Slides and dried at room temperature for over-night. The sections were deparaffinized in xylene and hydrated and rehydrated in graded solutions of ethanol. The endogenous peroxidase was blocked with Peroxidazed 1 (Bioca

• br Discussion br The pancreas

  2022-08-16

  

  4. Discussion The pancreas is an organ in which inflammation, fibrosis and atrophy are easily induced because most of the pancreatic parenchyma is composed of acini that produce digestive enzymes [31]. However, the significance of the changes in acinar morphology within the sur-rounding microen

• Cy5.5 NHS ester From the relative risk model an estimate of the relative

  2022-08-15

  

  From the relative risk model, an estimate of the relative cancer risk coefficient (β) is obtained, expressed as risk per internal dose. This coefficient is assumed to be approximately independent of tumor site, sex, and Cy5.5 NHS ester (Granath et al., 1999). The relative risk could also be express

• br The morphology of MSNs was

  2022-08-15

  

  The morphology of MSNs was characterized by TEM. As shown in Fig. 1A, MSNs presented a uniform size around 100 nm, a spherical shape, a well particle monodispersity, as well as an obvious mesoporous structure. For DOX/[email protected], a clear thin layer surrounded MSNs in Fig. 1B demonstrated the succe

• br Appendix A Supplementary data br

  2022-08-15

  

  Appendix A. Supplementary data References A. Bofin, G.M. Maelandsmo, L.A. Akslen, O. Engebraaten, I.S. Gribbestad, In vivo MRI and histopathological assessment of tumor microenvironment in luminal-like and basal-like breast cancer xenografts, J. Magn. Reson. Imaging 35 (5) (2012) 1098–1107.

• br Cancer s http www glpbio com simage GC

  2022-08-11

  

  Cancer stem cells STAT3 Metastasis  Triple-negative breast cancer (TNBC) is an aggressive heterogeneous disease with a divergent profile. It has an earlier tendency to form metastases and is associated with poor clinical outcomes due to the limited treatment options available. Heat-shoc

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