br We provide what to our knowledge is the first
We provide what to our knowledge is the first evidence to sup-port the recently changed NCCN guidelines recommending post-surveillance imaging and examination at 3 to 6 months after definitive treatment. Of note, however, our findings suggest that somewhat more frequent follow-up than this is probably preferable, because patients with asymptomatic recurrences detected on imag-ing fared better in our cohort. These findings also raise the question of whether periodic repeat Mocetinostat (MGCD0103, MG0103) imaging might be of benefit in the asymptomatic patient. Optimally, our findings should be validated in a prospective randomized controlled trial or (more realistically) a larger retrospective analysis of pooled patients from multiple in-stitutions to better define an optimal posttreatment surveillance interval after curative-intent CRT.
Clinical Practice Points
The optimal surveillance frequency after definitive CRT for stage III NSCLC patients is unknown.
Most relapses after definitive CRT for stage III NSCLC happen within 1 year of completing treatment.
Symptomatic relapses result in worse OS compared to asymp-tomatic relapses identified by surveillance imaging.
More aggressive surveillance imaging may improve outcomes by identifying asymptomatic relapses that are amenable to earlier salvage therapy.
The authors have stated that they have no conflict of interest.
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