• 2022-09
  • 2022-08
  • 2022-07
  • 2022-05
  • 2022-04
  • 2021-03
  • 2020-08
  • 2020-07
  • 2018-07
  • br P value between the variable and the


    * P value between the variable and the endpoint diastolic function of the left ventricle, calculated using linear regression analysis.
    This study shows an association between individual RT dose for BC and GLS of the LV. Our results suggest that these adverse effects are associated with radiation dose to the coronary arteries. Diastolic function was associated with age and Herboxidiene at time of BC diagnosis; DVH parameters were less frequently selected for this endpoint.
    3. Harris EE, Correa C, Hwang WT, et al. Late cardiac mortality and morbidity in early-stage breast cancer patients after breast-conservation treatment. J Clin Oncol 2006;24:4100-4106.
    6. van den Bogaard VAB, Ta BDP, van der Schaaf A, et al. Validation and Modification of a Prediction Model for Acute Cardiac Events in Patients With Breast Cancer Treated With Radiotherapy Based on Three-Dimensional Dose Distributions to Cardiac Substructures. J Clin Oncol 2017;35:1171-1178.
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    18. Nagueh SF, Appleton CP, Gillebert TC, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiog-raphy. J Am Soc Echocardiogr 2009;22:107-133.
    20. Van der Schaaf A, Xu CJ, van Luijk P, et al. Multivariate modeling of complications with data driven variable selection: Guarding against overfitting and effects of data set size. Radiother Oncol 2012;105: 115-121.
    21. Magne┬┤ N, Castadot P, Chargari C, et al. Special focus on cardiac toxicity of different sequences of adjuvant doxorubicin/docetax-el/CMF regimens combined with radiotherapy in breast cancer pa-tients. Radiother Oncol 2009;90:116-121.
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    23. Gustavsson A, Bendahl PO, Cwikiel M, et al. No serious late cardiac effects after adjuvant radiotherapy following mastectomy in premen-opausal women with early breast cancer. Int J Radiat Oncol Biol Phys 1999;43:745-754.
    24. Cikes M, Solomon SD. Beyond ejection fraction: An integrative approach for assessment of cardiac structure and function in heart failure. Eur Heart J 2016;37:1642-1650.