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br min To visualize cellecell adhesion
2020-08-30
60 min. To visualize cellecell adhesion, immunofluorescence staining was chosen. The cultured ABT-888 were treated with the E-cadherin (CDH1) primary antibody (Takara Bio) overnight at 4 C and dyed with the secondary antibody conjugated with Alexa Fluor 555 (Life Technologies) for 30 min at roo
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br Results br DSC targets TOPK but not MEK br
2020-08-30
Results 3-DSC targets TOPK, but not MEK To determine whether 3-DSC affects TOPK activity, we conducted a TOPK kinase assay (Fig. 1A). 3-DSC inhibited TOPK kinase activity, as compared to the vehicle control but did not affect the kinase activity of MEK, which also belongs to the MAPKK family (
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br D Endocytosis E Drug
2020-08-28
(D) Endocytosis. (E) Drug release mediated by Cathepsin B. (F) Tumor cell death. Adapted with permission from Ref. [112]. Fig. 9. Synthesis of gatekeeper-supported functionalization with 3-(azidopropyl)triethoxysilane capped with peptide sequence and further delivery of Doxby action of Cathepsi
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br d Mayo Clinic Department
2020-08-28
d Mayo Clinic, Department of Pathology, United States of America e Mayo Clinic, Department of Biomedical Statistics and Informatics, United States of America • Cancer predisposition gene mutations were found in 4–6% of patients with EC. • Frequency of LS mutations was similar in both type
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br Radiation BCF br No Radiation
2020-08-28
Radiation + BCF No Radiation control photon Brain Days after irradiation BCF Sham ns * BCF Vehicle Ethosuximide BCF VGCCs play major roles in tumour progression [48]. Specifically, T-type channels are known for both oncogenic and tumour suppressive functions in a
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br Initially miR p was
2020-08-18
Initially, miR-126-3p was noted to be poorly expressed, whereas ADAM9 was highly expressed in pancreatic cancer cell lines, with our results suggesting that miR-126-3p could directly inhibit the LDN193189 of ADAM9. Studies have indicated that miR-126-3p is poorly expressed in various tumors, incl
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br Grant support br This study was
2020-08-18
Grant support This study was supported by Helse Vest, the University of Bergen, the Norwegian Cancer Society, the Research Council of Norway, Bergen Research Foundation, by the Dutch Cancer Society (‘KWF Kankerbestrijding’: www.kwf.nl), contract number UM-13-5782 granted to RA and by Biocenter
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br The preparation of BPNs were performed
2020-08-18
The preparation of BPNs were performed via liquid exfoliation of bulk BP. During the course of liquid exfoliation, the transformation of bulk BP structure was characterized by Raman spectrum and X-ray diffraction (XRD). As shown in Fig. S1, peaks with similar Raman shift were observed at 362, 437,
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br Optimization br The desirability function was determined
2020-08-18
3.7. Optimization The desirability function was determined using Design Expert Software to achieve the optimized formulation. The optimum for-mulation was based on the set criteria of maximum EE, maximum zeta potential, minimum particle size, minimum PdI and RE8% in the range. Based on the mode
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br Introduction br Cancer is still
2020-08-18
1. Introduction Cancer is still a serious disease in today's world, and the annual morbidity and mortality rate remain high in the world. Studies have shown that colorectal cancer is a malignant tumor with a very high mortality.1 Although tumor treatment methods tend to be diversified in recent
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br In gastric cancer tissues ARPC
2020-08-18
In gastric cancer tissues, ARPC2 expression is associated with lymph node invasion and poor prognosis [22]. It was also reported that the upregulation of the ARPC4 promotes hepatocellular carcinoma (HCC) tumor progression and metastasis, which reduces the overall survival of HCC patients [47]. The
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br The calculation model adopts first
2020-08-18
The calculation model adopts first-order autoregressive model and mization calculation process to maximize the value of following model: θ The simplified model for parameter σwi in the model of Formula (18) can be obtained through parameter simplification process, in the form of:
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br The thermal properties of native BC
2020-08-18
The thermal properties of native BC and BC/LMN were detected by thermogravimetric analysis (TGA) (Fig. 2F). The unbound water con-tent was observed in the temperature range between 30 °C and 80 °C. The percentage weight loss was approximately 2.72% for BC and 11.45% for BC/LMNs at 520 °C. The resu
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br Results br The baseline characteristics
2020-08-14
3. Results The baseline characteristics of participants included in the final analysis are described in Table 1. A larger portion of women used any sedative-hypnotic medication compared with men; among women, 53% were prescribed any one of the sedative-hypnotics Table 1 General characteri
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Gathirua Mwangi WG Monahan PO Murage MJ Zhang
2020-08-14
[25] Gathirua-Mwangi WG, Monahan PO, Murage MJ, Zhang J. Metabolic syndrome and total cancer mortality in the Third National Health and Nutrition Examination Sur-vey. Cancer Causes Control 2017;28(2):127–36. [36] Schmitz KH, Neuhouser ML, Agurs-Collins T, Zanetti KA, Cadmus-Bertram L, Dean LT, et